| Issue | #21 |
| Published | June 2004 |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Axel Alonso; Jennifer Lee (Assistant Editor) |
| Notes | Two issues published in June. This is the first issue under the Marvel Knights imprint. |
| Characters | The Orphan; The Vivisector; The Anarchist; Dead Girl; Venus Dee Milo; Doop; Avengers; Vision; Iron Man; Captain America; Thor; Scarlet Witch; Hawkeye; Ant-Man; Wasp |
| Genre | Superhero |
| Pencils | Mike Allred |
| Inks | Mike Allred |
| Colors | Laura Allred |
| Notes | Two issues published in June. This is the first issue under the Marvel Knights imprint. |
| Genre | Superhero |
| Letters | typeset |
| Notes | Recap of the events which led to the start of this issue, illustrated with cover art from issue #21. |
| Characters | The Orphan [Guy Smith]; Venus Dee Milo; Captain America; The Vivisector [Myles Alfred]; Deadgirl; The Anarchist [Tike Alicar]; Doop; Avengers; Thor; Iron Man; Hawkeye; Scarlet Witch; Ant-Man |
| Genre | Superhero |
| Script | Peter Milligan |
| Pencils | Mike Allred |
| Inks | Nick Craine |
| Colors | Laura Allred |
| Letters | Nate Piekos [as Blambot's Nate Piekos] |
| Notes | "The Good and the Famous" Part 1 of 7. |
| Notes | Total of 12.33 one-page advertisements for: Alias (game, Acclaim), Soup at Hand (soup, Campbel, 0.33 page), Laffy Taffy (candy, Wonka/Nestle), Hot Cellphone Games (games, M-Forma Games), milk (milk, America's Dairy Farmers), Daredevil (game, Encore), Marvel Trading Card Game (collectible card game, UpperDeck), Midtown Comics (comic shop, Midtown Comics), Marvel Action Hero Bowling Club (bowling balls, Brunswick), Haircut for Heroes (haircutting kit, Wahl), With Great Selection Comics Great Responsibility (back issues, Mycomicshop.com), Babylon 5: 5th Season (dvd, WB), The Punisher (movie, Lionsgate). |