| Issue | #2 |
| Published | August 2010 |
| Frequency | monthly |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Tom Brennan |
| Characters | Spider-Girl; Punisher |
| Genre | superhero |
| Pencils | Ron Frenz (signed) |
| Inks | Sal Buscema (signed) |
| Colors | Chris Sotomayor (signed) |
| Characters | Spider-Girl [May Parker]; Mayhem [April Parker]; Punisher; Don Silvio Baracca [Silverback]; Peter Parker; Mary Jane Watson-Parker; Benjamin Richard Parker; Captain Margarita Ruiz; Wes Westin; Courtney Duran; Heather Noble; Jimmy Yama; Detective Vinnie Drasco; Handsome Richie Valentine; Man-Mountain Marko; Phil Urich (cameo); Davida Kirby (cameo); Moose Mansfield (cameo) |
| Synopsis | Spider-Girl fights Mayhem when she finds her working with Man-Mountain Marko, and later runs into the Punisher. Meanwhile, both Wes and Courtney seem to know more about May than they should. |
| Genre | superhero |
| Script | Tom DeFalco; Ron Frenz (Co-Plot) |
| Pencils | Ron Frenz |
| Inks | Sal Buscema |
| Colors | Bruno Hang |
| Letters | Dave Sharpe |
| Characters | Benjamin Richard Parker |
| Synopsis | Benjy wears himself out with wallcrawling. |
| Genre | superhero; humor |
| Script | Tom DeFalco |
| Pencils | Colleen Coover |
| Inks | Colleen Coover |
| Colors | Colleen Coover ? |
| Letters | Colleen Coover ? |
| Characters | The Buzz [Jack Jameson]; American Dream; Richie Robertson; Handsome Richie Valentine |
| Synopsis | The Buzz and American Dream rescue mobster Richie Valentine from a fire (started in this issue's Spider-Girl story). |
| Genre | superhero |
| Script | Tom DeFalco; Ron Frenz (Co-Plot) |
| Pencils | Ron Frenz |
| Inks | Sal Buscema |
| Colors | John Kalisz |
| Letters | Dave Sharpe |