| Issue | #6 |
| Published | May 2010 |
| Frequency | monthly |
| Cover Price | 3.99 USD |
| Pages | 52 |
| Editing | Tom Brennan; Stephen Wacker (Supervising Editor) |
| Characters | Lizard |
| Genre | superhero |
| Pencils | Jelena Djurdjevic (painted) |
| Inks | Jelena Djurdjevic (painted) |
| Colors | Jelena Djurdjevic (painted) |
| Notes | Introductory page including table of contents and credits. |
| Characters | Lizard [Dr. Curt Connors]; Man-Thing [also appears in flashback as Ted Sallis]; Spider-Man (flashback) |
| Synopsis | In the Florida swamps where he first fought Spider-Man, the Lizard encounters Man-Thing and recalls their past connection. |
| Genre | superhero |
| Script | Fred Van Lente |
| Pencils | Jefte Palo |
| Inks | Jefte Palo |
| Colors | Javier Rodriguez |
| Letters | Joe Caramagna |
| Characters | Spider-Girl [also appears as May Parker]; Mayhem [also appears as April Parker]; Man-Mountain Marko; Black Tarantula; Chesbro; Araña; Captain Margarita Ruiz; Detective Vinnie Drasco; Code: Blue; Don Silvio [Silverback]; Peter Parker; Mary Jane Watson-Parker; Wes Westin; Jimmy Yama; Gene Thompson |
| Synopsis | Spider-Girl's attempt to defuse the gang war by bringing the Black Tarantula into contact with the police fails due to April's carelessness. Unknown to May, April has taken the identity of Mayhem and allied herself with Man-Mountain Marko. |
| Genre | superhero |
| Script | Tom DeFalco; Ron Frenz (Co-Plot) |
| Pencils | Ron Frenz |
| Inks | Sal Buscema |
| Colors | Bruno Hang |
| Letters | Dave Sharpe |
| Characters | Dr. Curt Connors [also appears as the Lizard in flashback]; Spider-Man (flashback) |
| Synopsis | Curt Connors realizes that he is losing the will to keep his transformation into the Lizard under control. |
| Genre | superhero |
| Script | Zeb Wells |
| Pencils | Xurxo Penalta |
| Inks | Xurxo Penalta |
| Colors | Matt Hollingsworth |
| Letters | Jared K. Fletcher |
| Notes | Story continues in Amazing Spider-Man (Marvel, 2003 series) #630. |