| Issue | #4 |
| Published | March 2010 |
| Frequency | monthly |
| Cover Price | 3.99 USD |
| Pages | 52 |
| Editing | Tom Brennan; Stephen Wacker (Supervising Editor) |
| Characters | Mysterio |
| Genre | superhero |
| Pencils | Jelena Djurdjevic (painted) |
| Inks | Jelena Djurdjevic (painted) |
| Colors | Jelena Djurdjevic (painted) |
| Letters | typeset |
| Notes | Introductory page including table of contents and credits. |
| Characters | Mysterio [Quentin Beck]; Ray Bradhaus; Dr. Strange |
| Synopsis | Mysterio thinks he has stolen his mentor's greatest secret, but he doesn't realize that the "special effect" is really a supernatural one. |
| Genre | superhero |
| Script | Fred Van Lente |
| Pencils | Barry Kitson |
| Inks | Barry Kitson |
| Colors | Jeromy Cox |
| Letters | Joe Caramagna |
| Characters | Spider-Girl [May Parker]; Spider-Girl [April Parker]; Fury [Goblin Queen]; Darkdevil; Peter Parker; Captain Margarita Ruiz; Rene DeSantos; Simone DeSantos; Kaine; Arthur Weadon; Davida Kirby; Wes Westin; Courtney Duran; Jimmy Yama; Heather Noble; Don Silvio [Silverback]; Man-Mountain Marko; Black Tarantula (cameo); Chesbro (cameo); Araña (cameo) |
| Synopsis | May and Darkdevil continue their battle against Fury and April, but April finally comes around to help them against Fury. Meanwhile, Arthur Weadon has Rene DeSantos released from custody, Don Silvio retaliates against the Black Tarantula, and Wes seems to come to a surprising realization. |
| Genre | superhero |
| Script | Tom DeFalco; Ron Frenz (Co-Plot) |
| Pencils | Ron Frenz |
| Inks | Sal Buscema |
| Colors | Bruno Hang |
| Letters | Dave Sharpe |
| Characters | Hammerhead; the General |
| Synopsis | Hammerhead is setting up his future plans for the day that Mr. Negative is no longer the crime boss of New York. |
| Genre | crime |
| Script | Frank Tieri |
| Pencils | Eric Canete |
| Inks | Eric Canete |
| Colors | Andres Mossa |
| Letters | Jared K. Fletcher |