| Issue | #4 |
| Published | December 2009 |
| Cover Price | 2.99 USD |
| Pages | 36 |
| Editing | Axel Alonso; Sebastian Girner (Assistant) |
| Characters | Deadpool; Zombie Deadpool |
| Genre | superhero |
| Pencils | Arthur Suydam (Painted) |
| Inks | Arthur Suydam (Painted) |
| Colors | Arthur Suydam (Painted) |
| Letters | Typeset |
| Notes | Cover is a tribute to the movie poster for Scarface. |
| Genre | superhero |
| Pencils | Bong Dazo |
| Inks | Jose Pimentel |
| Colors | Matt Milla |
| Letters | Typeset |
| Characters | Deadpool; GUESTS: Dr. Betty Swanson; Zombie Deadpool; VILLAINS: Hydra; AIM |
| Synopsis | While Betty escapes with Zombie Deadpool's head, DP battles a zombified t-rex and gets some unexpected (and probably unwanted) help from an AIM orbital platform that blows them both to smithereens; After 'Pool mostly regenerates from his impromptu trial by fire, they steal a Hydra ship and head up to the AIM satellite to rendezvous with Betty's AIM bosses and turn over the head; Hydra follows. |
| Genre | superhero |
| Script | Victor Gischler |
| Pencils | Bong Dazo |
| Inks | Jose Pimentel |
| Colors | Matt Milla |
| Letters | Jeff Eckleberry |
| Characters | Deadpool; Zombie Deadpool; Dr. Betty Swanson |
| Genre | superhero |
| Pencils | Arthur Suydam (Painted) |
| Inks | Arthur Suydam (Painted) |
| Colors | Arthur Suydam (Painted) |
| Letters | Typeset |
| Notes | Presents full page cover art for next issue. |