| Issue | #600 |
| Published | September 2009 |
| Cover Price | 4.99 USD |
| Pages | 108 |
| Editing | Stephen Wacker; Thomas Brennan (Assistant) |
| Characters | Spider-Man; Dr. Octopus [arms] |
| Genre | superhero |
| Pencils | Alex Ross (Painted) |
| Inks | Alex Ross (Painted) |
| Colors | Alex Ross (Painted) |
| Letters | Typeset |
| Notes | There is a Dynamic Forces variant of this cover with no logo and the image in blue instead of red and limited to 3,499 copies. |
| Characters | Spider-Man |
| Genre | superhero |
| Pencils | John Romita Jr. |
| Inks | Klaus Janson |
| Colors | Dean White |
| Letters | Typeset |
| Notes | Wraparound cover |
| Characters | Spider-Man; Aunt May Parker; J. Jonah Jameson Sr.; Robbie Robertson; Carlie Cooper; Betty Brant; Harry Osborn; Norman Osborn; Mary Jane Watson; J. Jonah Jameson |
| Genre | superhero |
| Pencils | John Romita |
| Inks | John Romita |
| Colors | Marcos Martin |
| Letters | Typeset |
| Notes | Variant cover distributed 1:25 with the regular covers. |
| Characters | Spider-Man |
| Genre | superhero |
| Pencils | Joe Quesada |
| Inks | Danny Miki |
| Colors | Morry Hollowell |
| Letters | Typeset |
| Notes | Wraparound cover; Variant cover distributed 1:15 with the regular covers. |
| Characters | Dr. Octopus |
| Genre | superhero |
| Pencils | John Romita Jr. |
| Inks | Klaus Janson |
| Colors | Dean White |
| Letters | Typeset |
| Notes | 2nd print variant utilizes an interior splash page as the cover image. |
| Genre | superhero |
| Pencils | Jack Kirby |
| Inks | Steve Ditko |
| Colors | Stan Goldberg |
| Letters | Typeset |
| Notes | Recap page is done as a wedding invitation for Aunt May and J. Jonah Jameson Sr. with a tiny reproduction of a cover detail from Amazing Fantasy #15. |
| Characters | Spider-Man; GUESTS: Aunt May Parker; J. Jonah Jameson Sr.; J. Jonah Jameson; Daredevil; Avengers [Captain America [Bucky Barnes]; Luke Cage; Ronin [Clint Barton]; Wolverine; Spider-Woman [Jessica Drew]]; Fantastic Four [Mr. Fantastic; Invisible Woman; Human Torch; The Thing]; Ben Urich; Sally Floyd; Robbie Robertson; Martha Robertson; Randy Robertson; Norah Winters; Anna Watson; Carlie Cooper; Michele Gonzales; Betty Brant; Flash Thompson; VILLAINS: Dr. Octopus; 8-Ball; Boomerang; Blindside; Hydro-Man; CAMEO FLASHBACK: Captain America [Steve Rogers]; Hammerhead; Ultron; Hulk; Sandman; CAMEO: Mary Jane Watson |
| Synopsis | Dr. Octopus learns from a medical doctor that his condition is terminal and decides to go out with a bang; He transforms himself by plugging his brain into computers everywhere and deploys hundreds of little octopus bugs; As Spidey prepares for the upcoming wedding of Aunt May and Jameson Sr., he is astonished as the city of New York literally begins to attack him; Doc Ock appears on screens all over the city and proclaims his plans for making first New York and then the world a veritable utopia where all technology works properly thanks to his intervention; The Avengers and Fantastic Four get involved in trying to rectify the situation; Spidey and the Human Torch track Ock down and rescue Jay Sr., Carlie and Norah who have been captured; Spider-Man battles this new incarnation of Dr. Octopus but the villain gets away; Aunt May and J. Jonah Jameson Sr. are married with Peter as the best man and JJJ Jr. performing the ceremony; Pete immediately hits his new brother-in-law up for a loan; Aunt May throws the bouquet and it is caught by a late and surprise arrival, Mary Jane Watson. |
| Genre | superhero |
| Script | Dan Slott |
| Pencils | John Romita Jr. |
| Inks | Klaus Janson |
| Colors | Dean White |
| Letters | Virtual Calligraphy's Joe Caramagna |
| Characters | Spider-Man; GUEST: Dr. Gray Madder [Stan Lee]; CAMEO FLASHBACK: Spider-Ham; Mary Jane Watson; Harry Osborn; Gwen Stacy; Green Goblin |
| Synopsis | Spidey visits a rather familiar looking psychiatrist to unload all of his problems but his life turns out to be so crazy that the shrink turns out to need psychiatric treatment of his own. |
| Genre | superhero |
| Script | Stan Lee |
| Pencils | Marcos Martin |
| Inks | Marcos Martin |
| Colors | Javier Rodriguez |
| Letters | Virtual Calligraphy's Joe Caramagna |
| Characters | Spider-Man; Luke Cage; Spider-Man Jr.; Luke Cage Jr. |
| Genre | superhero; humor |
| Script | Jeph Loeb |
| Pencils | Mike McKone |
| Inks | Andy Lanning |
| Colors | Morry Hollowell |
| Letters | Chris Eliopoulos |
| Notes | Fake Spider-Man cover that pits Spidey's son against Cage's boy. |
| Characters | Peter Parker [Spider-Man]; Norman Osborn; Mary Jane Watson; Gwen Stacy; J. Jonah Jameson; Robbie Robertson; Aunt May Parker; Harry Osborn; Carlie Cooper |
| Genre | superhero; humor |
| Script | Ed Brubaker |
| Pencils | Mike McKone |
| Inks | Andy Lanning |
| Colors | Andres Mossa |
| Letters | Chris Elipoulos |
| Notes | Fake Spider-Man cover that parodies the cover to Amazing Spider-Man Annual #21 and depicts Peter and MJ having a double wedding with Norman and Gwen. |
| Characters | Peter Parker [Spider-Man]; GUESTS: Uncle Ben Parker; Aunt May Parker; CAMEO FLASHBACK: Richard Parker; Mary Parker |
| Synopsis | Uncle Ben struggles with the job of raising his nephew. |
| Genre | superhero |
| Script | Mark Waid |
| Pencils | Colleen Doran |
| Inks | Colleen Doran |
| Colors | Jose Villarrubia |
| Letters | Virtual Calligraphy's Joe Caramagna |
| Characters | Spider-Man; Sgt. Hippie |
| Genre | superhero; humor |
| Script | Matt Fraction |
| Pencils | Mike McKone |
| Inks | Andy Lanning |
| Colors | Frank D'Armata |
| Letters | Chris Eliopoulos |
| Notes | Fake Spider-Man cover parodying the socially conscious comics of the 70's. |
| Characters | Spider-Man; CAMEOS: Hammerhead; Venom; Lizard |
| Synopsis | A group of school kids imagine what it would be like to be Spider-Man. |
| Genre | superhero |
| Script | Bob Gale |
| Pencils | Mario Alberti |
| Inks | Mario Alberti |
| Colors | Mario Alberti |
| Letters | Jared K.Fletcher |
| Characters | Aunt May; CAMEO FLASHBACK: Spider-Man; Green Goblin; Venom; J. Jonah Jameson Sr. |
| Synopsis | Aunt May visits Uncle Ben's grave and seeks his blessing in her upcoming marriage to Jameson Sr. |
| Genre | superhero |
| Script | Marc Guggenheim |
| Pencils | Mitch Breitweiser |
| Inks | Mitch Breitweiser |
| Colors | Elizabeth Breitweiser |
| Letters | Virtual Calligraphy's Joe Caramagna |
| Characters | Peter Parker [Spider-Man]; GUEST: Norah Winters |
| Synopsis | Peter and Norah are covering a super hero tech display at the Museum of Design when a group of kids start making fun of the Spider-Mobile. |
| Genre | superhero |
| Script | Zeb Wells |
| Pencils | Derec Donovan |
| Inks | Derec Donovan |
| Colors | Antonio Fabela |
| Letters | Virtual Calligraphy's Joe Caramagna |
| Characters | Spider-Man; Batman |
| Genre | superhero; humor |
| Script | Brian Michael Bendis |
| Pencils | Klaus Janson |
| Inks | Klaus Janson |
| Colors | Andres Mossa |
| Letters | Chris Eliopoulos |
| Editing | Tom Brevoort |
| Notes | Fake Spider-Man cover featuring a Spidey Batman team-up with Batman's name and figure covered by notes from Marvel's legal department. Ironically, ther have already been two Spider-Man/Batman team-up comics published in 1995 and 1997. |
| Characters | Madame Web; VILLAINS: Kraven [Ana Kravinoff]; Sasha Nikolaevich; CAMEOS: Spider-Man; Spider-Woman [Jessica Drew]; Rhino; Black Cat; Arana; Lizard; Echo |
| Synopsis | Madame Web is viewing the future when she is attacked and captured by the new Kraven and her mother. |
| Genre | superhero |
| Script | Joe Kelly |
| Pencils | Max Fiumara |
| Inks | Max Fiumara |
| Colors | Chris Chuckry |
| Letters | Virtual Calligraphy's Joe Caramagna |
| Notes | Story is a quick preview of upcoming events as cameo panels feature scenes from future stories. |